The attenuation of seismic coda waves in the Southern Appalachian region was studied. Signal sources were five local and regional earthquakes and one explosion located in Ohio, Virginia and South Carolina. The data were recorded digitally by a network of seven stations in western Virginia. Joint least squares estimates of the quality factor Q, relative recording site response and coda source amplitudes were obtained in five frequency bands using the single scattering model, and assuming body wave geometrical spreading. The results indicate a frequency dependent coda Q, represented by Q=811 f0.42, 1.5≤f≤12 Hz, for lapse times in the range 15 to 250 seconds. Site responses determined relative to the average network response differ by less than a factor of 2 in the range 3 to 12 Hz at five of the seven stations. However, the differences in the response of the other two sites increase with frequency, amounting to a factor of 5 at 12 Hz. Estimated relative coda source amplitude spectra exhibit similar shapes, consistent with the assumption that the scattering process is independent of path in the study region. ¿ American Geophysical Union 1989