Aeronomic observations applied to the empirical derivation of the ion-neutral collision cross-section-a basic parameter governing the mutual interactions between the neutral and plasma components in the Earth's upper atmosphere-have given values considerably larger than those derived from theory. The empirical scheme uses the plasma velocities obtained with the Incoherent Scatter Radar and the neutral winds obtained with the Fabry-Perot Interferometer. It is shown here that such an analysis overestimates the collision cross-section due to the effects of errors in the observables. The effect may be sufficiently large to bring about agreement with theory, and calls for a re-analysis of the aeronomic data using methods which minimize the bias caused by measurement errors.