Numerical simulations reveal that variations in wind stress and heat fluxes can induce significant interannual fluctuations in the circulation of the upper layers of the Mediterranean. From January 1980 to November 1988, the atmosphere shows changes in the structure and magnitude of the surface winds and in the air temperatures which induce modifications in the upper ocean structure and currents. The model prediction of the interannual fluctuations of the Sicily Strait baroclinic westward volume transport is in agreement with observations and the variability is explained as a function of the wind curl forcing in the region. The current anomalies persist for many months after a Winter atmospheric anomalous disturbance has occurred over the basin. The Eastern Mediterranean basin is the area where the interannual ocean response is most pronounced.¿ 1997 American Geophysical Union