Nearly continuous measurements of carbon monoxide (CO) were made at Shenandoah National Park-Big Meadows in rural Virginia, a site considered representative of regional air quality, from December 1994 to November 1997. Similar observations were also made at this location from October 1988 to October 1989. These observations combine to indicate a decreasing trend in CO concentration over the U.S. mid-Atlantic region of about 5.0 ppbv yr-1, with greater than 95% confidence that the slope is significantly different from zero. The decrease suggests U.S. reductions in anthropogenic CO emissions have been effective in reducing pollutant levels. The observed trend is consistent with the U.S. EPA reported trend in emissions and the decrease in Northern Hemisphere tropospheric background CO mixing ratios observed by other researchers. ¿ 1999 American Geophysical Union