Ionization irregularities which are almost but not exactly aligned along the magnetic field may grow much more rapidly than purely aligned irregularities in the presence of a background gradient of ionization and current flow. The stability of these irregularities is considered, taking into account the finite thickness of the gradient and shear in the ion motion. It is shown in particular that the normal E region of the ionosphere is usually stable, whereas sporadic E is often unstable, and this may limit the compression of metallic ions to form such layers. The F region may sometimes be unstable. Temperature zone conditions are considered throughout.