The ionization rate of helium in the thermosphere is inferred from AE-E ion and neutral particle composition measurements, made on several days during solar cycle 21, in the context of a steady state photochemical model for helium ions. The inferred ionization rate varies by a factor of 4 between July 1976 and January 1979, a value consistent with the variation in the flux measured during the same period by the EUV spectrometer on board the AE-E satellite.