The seasonal averages of the equatorial F region vertical and zonal plasma drifts are determined using extensive incoherent scatter radar observations from Jicamarca during 1968-1988. The late afternoon and nightime vertical and zonal drifts are strongly dependent on the 10.7-cm solar flux. We show that the evening prereversal enhancement of vertical drifts increases linearly with solar flux during equinox but tends to saturate for large fluxes during southern hemisphere winter. We examine in detail, for the first time, the seasonal variation of the zonal plasma drifts and their dependence on solar flux and magnetic activity. The seasonal effects on the zonal drifts are most pronounced in the midnight-morning sector. The nighttime eastward drifts increase with solar flux for all seasons but decrease slightly with magnetic activity. The daytime westward drifts are essentially independent of season, solar cycle, and magnetic activity.