The seismicity of the northwestern Himalayan syntaxial bend and the geologically complex area to the west, betweeen the Hazara thrust system (HTS) and the higher mountains of Indus-Kohistan, is examined in a wider tectonic context by using data from about 1,800 microearthquake data were obtained from a telemetered seismic network in northern Pakistan centered at Tarbela dam on the Indus River and were collected during an 11-month period prior to impounding of the Tarbela reservoir. The observed seismicity indicates that a branch of the main boundary thrust (MBT) traverses the region as a straight northwesterly extension of the Muree thrust, the mapped section of the MBT southeast of the syntaxial bend along the Kashmir Himalayas. Seismic release on this extension of the MBT, here named the Indus-Kohistan seismic zone (IKSZ), is highest in the upper 25 km of the crust and correlates with a pronounced topographic step. Deeper activity on the IKSZ extends to a depth of 70 km. Seismicity in the lower crust defines a second lineation 100 km southwest of the IKSZ and parallel to it. The syntaxial bend and the eastern HTS, microseismically virtually inactive at present but associated with recent and historical microseismicity, overprint the two northwesterly seismic lineaments. The two tectonic regimes may be simultaneously active at different depths separated by an incompetent layer. A set of steeply dipping faults, either parallel or perpendicular to the IKSZ, is active in the region between the HTS and the IKSZ. Seventeen composite fault plane solutions show a predominant pattern of either reverse or strike slip faulting with the inferred slip vectors oriented such that north-south compressional stresses are relieved. Such a stress field is compatible with the north-south convergence between the Indian and Eurasian plates inferred from plate tectonics.