The field settings are described and analytical data are presented for six two-mica granites from northeastern Nevada. High Δ18O and 87Sr/86Sr values indicate that all are S-type granites, derived from continental crust. The major element chemistry and accessory mineral contents of these rocks also are characteristic of S-type granites. Chemical, X ray, and other data are presented for the micas recovered from these granites. The muscovites are notably high in Fe2O3, FeO, and MgO. Except for one hydrobiotite, each of the biotites has an MgO content near 6.0 weight percent. Two different types of two-mica granites are recognized in the area of this study. One type is distinguished by the presence of many biotite euhedra within muscovite phenocrysts and by an unusual suite of accessaroy minerals completely devoid of opaque oxides. This type probably resulted from anatexis of late Precambrian argillites under conditions of relatively low oxygen fugacity, along a line that roughly coincides with the westward disappearance of continental basement. In the other textural type of two-mica granite the micas are equigranular and there is a greater variety of accessory minerals. The magmatic evolution of this type also appears to reflect the influence of late Precambrian argillites; there may be age differences between the two types of two-mica granites.