Every large eruption of nonbasaltic magma taps a magma reservoir that is thermally and compositionally zoned. Most small eruptions also tap parts of heterogeneous and evolving magmatic systems. Several kinds of compositionally zoned ash flow tuffs provide examples of preeruptive gradients in T and fO2, in chemical and isotopic composition, and in the variety, abundance, and composition of phenocrysts. Such gradients help to constrain the mechanisms of magmatic differentiation operating in each system. Roofward decreases in both T and phenocryst content suggest water concentration gradients in magma chambers. Wide compositional gaps are common features of large eruptions, proving the existence of such gaps in a variety of magmatic systems. Nearly all magmatic systems are 'fundamentally basaltic' in the sense that mantle-derived magmas supply heat and mass to crustal systems that evolve a variety of compositional ranges. Feedback between crustal melting and interception of basaltic intrusions focuses and amplifies magmatic anomalies, suppresses basaltic volcanism, produces and sustains crustal magma chambers, and sometimes culminates in large-scale diapirism. Degassing of basalt crystallizing in the roots of these systems provides a flux of He, CO2, S, halogens, and other components, some of which may influence chemical transport in the overlying, more silicic zones. Basaltic magmas become andesitic by concurrent fractionation and assimilation of partial melts over a large depth range during protracted upward percolation in a plexus of crustal conduits. Zonation in the andesitic-dacitic compositional range develops subsequently within magma chambers, primarily by crystal fractionation. Some dacitic and rhyolitic liquids may separate from less-silicic parents by means of ascending boundary layers along the walls of convecting magma chambers.. Many rhyolites, however, are direct partial melts of crustal rocks, and still others fractionate from crystal-rich intermediate parents. The zoning of rhyolitic, magma is accomplished predominantly by liquid state thermodiffusion and volatile complexing; liquid structural gradients may be important, and thermal gradients across magma chamber boundary layers are critical. Intracontinental silicic batholiths form where extensional tectonism favors coalescence of crustal partial melts instead of hybridization with the intrusive basaltic magma. Cordilleran batholiths, however, result from prolonged diffuse injection of the crust by basalt that hybridizes, fractionates, and preheats the crust with pervasive mafic to intermediate forerunners, culminating in large-scale diapiric mobilization of partially molten zones from which granodioritic magmas separate. Much of the variability among magmatic systems probably reflects the depth variation of relative rates of transport of magma, heat, and volatile components, as controlled in turn by the orientation and relative magnitudes of principal stresses in the lithosphere, the thickness and composition of the affected crust, and variations in the rate and longevity of basaltic magma supply. Extension of the lithosphere may reduce the susceptibility of basaltic magmas to hybridization in the crust, but it can also enhance the role of mantle-derived volatiles in chemical transport.