We report new heat flow measurements at 25 evenly distributed sites in the north-central Colorado Plateau. Heat flow values computed for these new sites and one previously published site range from 43 to 116 mW m-2 but fall into the following district subsets related to physiographic and tectonic elements within the Plateau: (1) heat flow of 51 mW m-2 (12 sites; s.d. 6) in the San Rafael Swell and Green River Desert which constitute the core of the Colorado Plateau at this latitude, (2) heat flows of 69 mW m-2 (5 sites; s.d. 10) in successive parallel north-south bands approaching the Wasatch Plateau to the west but still 80 km east of the Basin and Range physiographic boundary, (3) heat flow of 64 mW m-2 (5 sites; s.d. 2) along the Salt Anticline trend which strikes northwest in the region of Moab, Utah. Heat flow results for the entire Colorado Plateau have been reexamined in view of our new results, and the overall pattern supports the concept of a low heat flow 'thermal interior' for the plateau surrounded by a periphery some 100 km wide having substantially higher heat flow. Average heat flow in the thermal interior is about 60 mW m-2 compared to 80--90 mW m-2 in the periphery. This regional heat flow pattern supports a model of tertiary lithospheric thinning under the Colorado Plateau whereby the plateau is still in transient thermal response and a 15--20 m.y. lag between uplift and corresponding surface heat flow anomaly is to be expected. The position of the heat flow transition between our interior and peripheral regions in the northwest plateau is roughly consistent with lateral warming and weakening of the Colorado Plateau lithosphere initiated at the Basin and Range boundary some 20 m.y. ago.