Mesozoic and Tertiary granite rocks in and adjacent to the northern Great Basin (NGB) in Nevada and Utah display a wide range of initial 143Nd/144Nd (&egr;Nd) and 87Sr/86Sr (&egr;Sr) values which vary regularly with geographic position. From the Klamath Mountains inland 500 km to central Nevada, granite &egr;Nd values decrease regularly from +8 to -6 and correlate with &egr;Sr values that increase from -20 to +60. In east-central Nevada, near the trace of the Roberts Mountains Thrust (RMT), the &egr;Nd values decrease from -6 to an average of -18, while &egr;Sr becomes highly variable with values generally greater than +100. These isotopic discontinuities correspond to the west-to-east facies transition from pelagic clastic sedimentary rocks to shelf carbonates and to the shift in the dominant granite bulk composition from metaluminous to peraluminous. In the eastermost NGB a second discontinuity in &egr;Sr occurs with values dropping to ~+60; average &egr;Nd remains at -18. Combined with known aspects of NGB geology the isotopic data suggest that west of the RMT, granites formed via interaction of magma derived from a LREE-depleted pelagic sedimentary rock. Variations in 87Rb/86Sr with Sr, and 147Sm/144Nd with &egr;Nd, indicate that crystal fractionation accompanied assimilation, but that plagioclase was not an important fractionaing phase. East of the RMT, granites appear to be primarily derived from Precambrian continental basement with little mantle input. THe isotopic discontinuities near the RMT mark the western edge of Precambrian basement and occur 100-200 km east of th 87Sr/86Sr (=0.7060) line of Kistler and Peterman <1973>. The &egr;Nd discontinuity in the eastern NGB marks a boundary between Rb-depleted (granulite?) lower continental crust to the east, and basemetn that has no 'depleted' lower crust to the west. The difference may be a result of lateral variations in metamorphic grade in the orogenic episode at ~1.7 b.y. ago or a result of ductile attenuation of the lower crust during the late Precambrian continental rifting. The basement age appears to be intermediate between Nd model ages due to changes in Sm/Nd during granite magma generation. In contrast to the eastern NGB granites. Mesozoic batholith granites of the western United States have a lowest &egr;Nd of only -8 even where thought to have been emplaced in crystalline basement, a difference which could be related to an island decreasing flux of mantle-derived magma into the continental crust in the Mesozoic. A model for subduction-induced flow in the upper mantle beneath the continent, resulting in perturbations in the thermal structure of the continental lithosphere is presented to account, in part, for the spatial difference in mantle magma flux and the distribution of silicic magmatism in the western United States. Overall, the NGB granite data support the concept that mantle magmas are added to continents mainly at the margin, with little mantle magma generation, or continental growth, inthe interior, and demonstrate the potential of Nd and Sr isotopic data from granites in discerning fundamental features of deep continental crust.