Segregation vesicles in seafloor basalts generally are sperical in shape, 0.1-0.3 mm in diameter, and partly filled with a dark, cup-shaped meniscus of chilled residual melt. This residue presumably enters the vesicles sometime after crystallization is sufficient to maintain the shape of the vesible but before final crystallization and flows to the bottom of the vesicle before solidifying. The orientation of the meniscus can therefore be used as an indicator of the cooling orientation of the rock. Results of statistical tests on 17 seafloor basalt samples previously oriented by megascopic geopetal features indicate that the meniscuses in segregation vesicles of a given rock sample are preferentially oriented about the earth's gravity field, as indicated by the megastopic features. In all cases there is consistency of segregation vesicle and megascopic orientations. As well, the distributions of magnetic inclinations of rocks oriented by megascopic features and segregation vesciles are similar. The segregation vesicle technique can be used to orient dredge and submersible samples for paleomagnetic polarity studies and to determine the dip and predeformational magnetic inclination of rocks recovered in drill cores, which have a known, in-place vertical orientation, if care is taken to select samples properly. Analyses of the scatter of segregation vesicle inclinations of 34 rock samples indicate that the error associated with dip and magnetic inclination determinations generally are less than ¿36¿ and ¿44¿, respectively. Of 158 submersible and dredge samples examined, 22% have segregation vesicles which can be used for rock orientation purposes and 30% of the rocks examined from DSDP cores have such vesicles. Routine application of the technique to such samples has the potential of significantly increasing knowledge of the structure and paleomagnetism of oceanic crust. A simple method for application of this technique is presented.