This paper presents a study of tectonic activity in China by means of fluid-geochemical methods. It is observed that deep fluids with characteristic chemical and isotopic compositions (high values of He and H2 and very low value of tritium) have migrated upward at some active faults. Many fluid-geochemical anomalies were observed during periods of seismic activity, suggesting the usefulness of fluid-geochemical methods for earthquake prediction. To properly select monitoring springs (or wells) and chemical components, local geological conditions have to be fully considered.