The late Tertiary subsidence history of the southern Levant continental margin, situated in the southeastern Mediterranean Sea, was quantitatively analyzed. Paleodepth reconstruction across the margin off Ashdod suggests the existence of a deep basin in pre-Messinian time which resembles the present one. This implies that the deposition of the evaporites in the study area during the Messinian desiccation of the Mediterranean Sea occurred in a deep basin. The path of the tectonic subsidence of the basement since early Tertiary is generally smooth as expected from the nature of the thermal subsidence. The unconformity beneath the Messinian indicates erosion of 50--200 m at the coastal plain. In the Pliocene, the tectonic subsidence in the coastal plain and shelf area diverts from the expected thermal path and increases from 250 m to 450 m, respectively. In the Quaternary the rate of tectonic subsidence nearly resumed the predicted thermal subsidence. Sedimentation and subsidence rates decrease but are still higher than those of the pre-Messinian. We suggest that the evolution of the southern Levant margin is most probably influenced by three main causes: (1) the Messinian event in late Miocene, (2) the deposition of large volumes of Nile derived sediments since the Pliocene, and (3) the flexural response of the lithosphere to the load from the Nile delta and/or from the uplift of the Judea Mountains (the western shoulder of the Dead Sea Transform). We interpret the latter to be the cause of the anomalous subsidence of the southern Levant margin during the Pliocene. ¿ American Geophysical Union 1992