This paper presents results of a paleomagnetic study of Oligo-Miocene red beds of the Tadjik depression in Central Asia. We sampled about 530 cores at 69 sites and six localities across the depression and along the western border of the Pamirs. Samples were thermally demagnetized and high-temperature components appear to predate folding of upper tertiary age. Throughout the depression, paleomagnetic inclinations are consistent with those observed on the stable Turan platform, at the western margin of the depression. However, they are shallower by about 30¿ than the inclination predicted from the reference apparent polar wander path. This appears to indicate a 23¿ difference in latitude, which is incompatible with paleogeographic reconstructions for the Tertiary. A sound interpretation of this anomaly would require a better-constrained Tertiary paleomagnetic reference for Asia. Inside the Tadjik depression, paleomagnetic declinations are all significantly rotated, counterclockwise with respect to those measured on the Turan platform. The eastern part of the depression is a domain of large rotation (52¿¿13¿ to 46¿¿15¿), whereas smaller amounts of rotation have occurred in the western part (27¿¿14¿ to 14¿¿15¿). The similarity between Tertiary and Cretaceous data available for the area shows that rotations have occurred since the Miocene. Little or no paleomagnetic rotations are observed in the ranges bordering the northern and western parts of the depression. Paleomagnetic and structural data suggest that block rotations in the Tadjik depression are associated with indentation of the Pamirs into stable Asia. At a larger scale, observed rotations are compatible with a model of regional sinistral wrenching, along a strip running from the Gulf of Oman to Lake Baikal. ¿ American Geophysical Union 1994