We compare water vapor measurements from the Naval Research Laboratory ground-based Water Vapor Millimeter-wave Spectrometer (WVMS) instruments with measurements taken by five space-based instruments. For coincident measurements the retrievals from all of the instruments show qualitatively similar altitude profiles. The retrieved mixing ratios from most instruments generally differ from an average calculated using retrievals from all of the instruments by <1 ppmv at most altitudes from 40 km to 80 km. Comparisons with the Microwave Limb Sounder (MLS) and the Halogen Occultation Experiment (HALOE) allow for the validation of observed temporal variations. The observed variations show similar annual and semiannual cycles. A comparison of several years of data from HALOE and WVMS also shows that the instruments are detecting similar interannual variations. A regression analysis of the WVMS and HALOE data sets shows that the observed variability is consistent within the estimated errors in the mesosphere and that in the upper stratosphere, where the natural variability is small, there is a positive correlation between the WVMS and the HALOE data.¿ 1997 American Geophysical Union