The 6-year wind archives from the Goddard Institute for Space Studies/Global Climate-Middle Atmosphere Model (GISS/GCMAM) were input to the GISS/Harvard/Irvine Chemical Transport Model (G/H/I CTM) to study the seasonal and interannual variability of the budgets and distributions of nitrous oxide (N2O) and trichlorofluoromethane (CCl3F), with the corresponding chemical loss frequencies recycled and boundary conditions kept unchanged from year to year. The effects of ozone feedback and quasibiennial oscillation (QBO) were not included. However, the role of circulation variation in driving the lifetime variability is investigated. It was found that the global loss rates of these tracers are related to the extratropical planetary wave activity, which drives the tropical upward mass flux. For N2O a semiannual signal in the loss rate variation is associated with the interhemispheric asymmetry in the upper stratospheric wave activity. For CCl3F the semiannual signal is weaker, associated with the comparatively uniform wave episodes in the lower stratosphere. The loss rates lag behind the wave activity by about 1--2 months. The interannual variation of the general circulation model generated winds drives the interannual variation of the annually averaged lifetime. The year-to-year variations of the annually averaged lifetimes can be about 3% for N2O and 4% for CCl3F. ¿ 1999 American Geophysical Union