The application of multiple collector inductively coupled plasma source mass spectrometry (MC-ICPMS) to 176 Lu- 176 Hf and 92 Nb- 92 Zr chronometry has been hampered by complex Zr-Hf purification procedures that involve multiple ion exchange column steps. This study presents a single-column separation procedure for purification of Hf and Lu by ion exchange using Eichrom ? Ln-Spec resin. The sample is loaded in pure HCl, and element yields are not dependent on the sample matrix. For 92 Nb- 92 Zr chronometry, a one-column procedure for purification of Zr using Biorad ? AG-1-x 8 resin is described. Titanium and Mo are completely removed from the Zr, thus enabling accurate 92 Zr measurements. Zirconium and Nb are quantitatively separated from rock samples using Eichrom Ln-Spec resin, allowing measurements of Zr/Nb with a precision of better than ?5% (2 ). The Ln-Spec and anion resin procedures may be combined into a three-column method for separation of Zr-Nb, Hf, Ta, and Lu from rock samples. For the first time, this procedure permits combined isotope dilution measurements of Nb/Ta, Zr/Hf, and Lu/Hf using a mixed 94 Zr- 176 Lu- 180 Hf- 180 Ta tracer. Analytical protocols for Zr and Hf isotope measurements using the Micromass Isoprobe, a second generation, single-focusing MC-ICPMS, are reported. Using the Isoprobe at M, 2 external precisions of ?0.5 units for Hf and Zr isotope measurements are achieved using as little as 5 ng (Hf) to 10 ng (Zr) of the element. The 176 Hf/ 177 Hf and Lu/Hf for rock reference materials agree well with other published MC-ICPMS and thermal ionization mass spectrometry (TIMS) data.