The science objective for the Solar-Stellar Irradiance Comparison Experiment (SOLSTICE) is to accurately measure the full disk solar spectral irradiance in the ultraviolet (UV) spectral region over a long time period. The SOLSTICE design was driven by the requirement for long-term, precise solar photometry conducted from space. The SOLSTICE 1 is on the Upper Atmosphere Research Satellite (UARS), launched in September 1991 with the possibility for a 10-year operational mission. The in-flight calibration for SOLSTICE to meet its primary objective is the routine measurements of the UV radiation from a set of early-type stars, using the identical optical elements employed for the solar observations. The extensive preflight calibrations of the instrument have yielded a precise characterization of the three SOLSTICE channels. Details of the preflight and in-flight SOLSTICE calibration are discussed in this paper. ¿ American Geophysical Union 1993