Laboratory data and cosmic ray doses are used to understand the irradiation-induced formation and destruction of organics in the outer layers (mantle) of a comet in the Oort cloud and for determining the fate of volatiles in the mantle. This is used to estimate the change in the orthowater/parawater ratio with depth in the outer layers of a new comet and the average thickness of the refractory part of the mantle of a new comet. Because comets will have large-scale irregularities, regions of the mantle will be unstable, leading to enhanced activity on a new comet and producing ''permanently'' active regions. ¿ American Geophysical Union 1991