Oxygen consumption, sulfide oxidation, and acid mine drainage (AMD) of pyritic mine tailings were investigated at Nanisivik Mine, which is located in an area with continuous permafrost on Baffin Island in northern Canada. Tailings of varying age and water content have been deposited under alkaline conditions. One area consisting of tailings deposited on land in 1992 was selected for detailed measurements of in situ oxygen uptake rates at the tailing surface in the summers 1998 and 1999 and periodically during autumn and winter in 1998. Measurements included oxygen gas, water content, and temperature in profiles, as well as chemical analyses of pore solution and solids. Additional oxygen consumption rates were measured under controlled temperature conditions on columns filled with partly oxidized tailings. On the basis of temperature dependency of pyrite oxidation observed in the laboratory, an Arrhenius diffusion equation with soil temperature as input was used to simulate the observed temporal variation in oxygen uptake. Field data reveal that the ongoing sulfide oxidation of well-drained tailings primarily takes place in the upper 30 cm and that oxidation has resulted in a depletion of pyrite, carbonates, and metals from this reaction zone. The model provides a reasonable fit to the observed trend in oxygen consumption and documents that oxidation of sulfide minerals in tailings is not reduced to neglectable levels at 0 ¿C. The AMD generation rate has been quantified based on the changes in concentration of oxidation products in the pore water and oxidation rates based on in situ measurements of oxygen consumption. The two rate descriptions provide comparable estimates of seasonal AMD generation and provide detailed information on weather-related controls of AMD generation, i.e., ground temperature, freezing, water content, and snow cover. These environmental controls are crucial for the design of frozen cover schemes in permafrost regions, where the aim is to force the frost table to the top of the tailings, maintaining tailings at subzero temperatures year-round and thereby controlling the AMD generation. ¿ 2001 American Geophysical Union