Stratigraphic, structural, metamorphic, and geochronologic studies of basement rocks in the Andean foothills and Coast Ranges of south central Chile (39¿--41 ¿S) suggest a protracted late Paleozoic to middle Mesozoic deformational and metamorphic history that imposes important constraints on the tectonic development of the southwestern Gondwana margin. In the study area the late Paleozoic paired metamorphic belt, coeval magmatic arc, and overlying Triassic sedimentary units preserve a record of Late Carboniferous to Early Permian subduction and arc magmatism, subsequent deep exhumation of the Western Series subduction complex, and diminished uplift and erosion of the Eastern Series arc-forearc region by the Late Triassic. Late Paleozoic structural elements and metamorphic assemblages formed during early subduction and arc magmatism, collectively referred to as D1, are largely erased in the Western Series by the dominant D2 schistosity and lower greenschist grade metamorphism. D1 structural features, as well as original sedimentary textures, are relatively well preserved in the less penetratively deformed Eastern Series. The regional distribution of late Paleozoic arc magmatism suggests that the late Paleozoic convergent margin deviated from a N-S trend north of this area to a NW-SE trend near this latitude and faced an open marine environment to the southwest. A transition from F2 isoclinal folding to more open, larger-scale F3 folds, interpreted as change in ductility during differential uplift of the Western Series, is not apparent in the Eastern Series. Despite a lesser degree of uplift during the main exhumational D2 event, delineation of unconformities and U-Pb dating of detrital zircons and intrusions into the Eastern Series allow tighter constraints to be placed on timing of uplift and denudation of the Eastern Series than on that in the Western Series. A regional unconformity exposed in the Lake District that separates more highly deformed Eastern Series lithologies from Late Triassic shallow marine to continental deposits suggests that substantial uplift also affected the inner forearc and magmatic arc region during the D2 event. We propose that dextral-oblique convergence, initiated during the middle Permian along this segment of the Gondwana margin, resulted in the transpressional uplift and juxtaposition of high pressure/temperature (P/T) Western Series against low P/T Eastern Series lithologies and culminated with deposition of Late Triassic, continental to shallow marine, coarse clastic sedimentary rocks in fault-bounded strike-slip basins adjacent to the exhumed Western Series. Large-scale dextral transpression and northward displacement of the accretionary complex during Late Permian to Late Triassic time along the Chilean margin of Gondwana are synchronous and kinematically compatible with widespread regional transpression, extension, and silicic magmatism inboard of the southern Gondwana margin at this time. ¿ 1999 American Geophysical Union