We used the Regional Atmospheric Modeling System (RAMS) model to investigate the possible impact of land cover change on the July climate of the coterminous United States over the last 290 years. Vegetation data were estimated using the Ecosystem Demography model. The observed change in land cover leads to a weak warming along the Atlantic coast and a strong cooling of more than 1 K over the Midwest and the Great Plains region. The precipitation signal is weaker and shows some reduction in the Midwest because of changes in the patterns of large-scale moisture advection.