In the northeastern segment of the North Patagonian Massif (southern Argentina), S to SW directed thrusting affected a Late Proterozoic to Cambrian phyllite succession and the Silurian to Lower Devonian Sierra Grande formation. Thrust tectonics was partly combined with the formation of mylonites and followed by the intrusion of the Navarrete granodiorite. Mylonites of the Tardugno granitoids are attributed to a ductile shear horizon in the subsurface. As second stage of deformation after cessation of thrusting, ~NW-SE compression led to the formation of widely distributed fold structures around NE-SW trending axes as well as SE directed reverse faults. It was followed by the late kinematic intrusion of a porphyric granite as final pulse of the Navarrete Intrusive Complex. Local folding around ~N-S to NW-SE trending axes represents the final stage of the compressive deformational history. Thrust tectonics plus subsequent stages of deformation can be assigned to the Late Paleozoic time interval, probably the Permian. They are seen in conjunction with the formation of granite mylonites within the North Patagonian Massif, the Cerro de los Viejos granite mylonite of the La Pampa Province, and the compressive structures in the Sierras Australes fold-and-thrust belt north of the boundary between Patagonia and Gondwana South America. Also, the lack of Early Paleozoic (Famatinian) deformation in this part of the North Patagonian Massif and the inferred boundary of the Early Paleozoic Cuyania (Precordillera) Terrane north of Patagonia support the interpretation that extra-Andean Patagonia collided with Gondwana South America during the Gondwanide orogeny. It is possible that Patagonia was part of a plate and that the long Gondwanide fold belt represented its collision zone.