Changes in the intensity of the oxygen minimum zone (OMZ) in the eastern tropical North Pacific over the past 140 kyr are recorded as enrichments and depletions of redox-sensitive metals in sediments of two piston cores, one within and one below the modern OMZ, from the continental margin off Mazatl¿n, Mexico (22¿41'N, 106¿28'W). Concentrations of Al (7.7 ¿ 0.6%), Ti (0.37 ¿ 0.03%), Fe (3.1 ¿ 0.25%), Mn (320 ¿ 31 ppm), and Ba (560 ¿ 82 ppm) in core NH15P (within the OMZ at 420 m water depth) were relatively constant over the last 110 kyr. In contrast, concentrations of Cd (4.8 ¿ 2 ppm), Cu (29.8 ¿ 9.1 ppm), U (9.1 ¿ 3.7 ppm), Mo (12.1 ¿ 5.0 ppm), V (138.2 ¿ 51.9 ppm), and Re (45.8 ¿ 25.5 ppb) were all at least 30% higher in interglacial stages compared to glacial stages. Concentrations of Al (7.4 ¿ 0.3%), Ti (0.35 ¿ 0.03%), Fe (3.5 ¿ 0.4%), and Mn (385 ¿ 77 ppm) in core NH22P (below the OMZ at 2025 m water depth) were comparable to those in core NH15P, while concentrations of Ba (1662 ¿ 292 ppm) were about a factor of three higher. In contrast, concentrations of Cd (0.9 ¿ 0.3 ppm), U (6.6 ¿ 0.9 ppm), Mo (3.2 ¿ 1.2 ppm), V (81.8 ¿ 10.1 ppm), and Re (25.4 ¿ 12 ppb) were lower in sediments of comparable age than the concentrations of these same metals in the OMZ core, and the differences in their concentrations over glacial-interglacial cycles were less pronounced than those in shallower core. Comparison of the nonlithogenic fraction of metals in the sediments with their estimated contribution from plankton suggests that organic matter is probably the major source of Cu, Ba, and perhaps Cd to the sediment, whereas the indirect effects of organic carbon and low bottom water oxygen concentrations on sediment redox state appear to be more important controls on the distributions U, Re, Mo, and V. Changes in the depth at which Re and Mo precipitated in the sediments and in the Re/Mo ratio suggest that the redox state of the surface sediment and overlying water at both core depths varied over time. Re and Mo removal depths were shallower and Re/Mo ratios were lower at the OMZ site than in deeper water, suggesting that a more reducing environment prevailed over time at the shallower site. Although the redox state of the waters and sediment at both sites varied over glacial-interglacial cycles, the OMZ likely was never anoxic in the last 140 kyr. This variability in redox state could be attributed to changes in regional export productivity, changes in ocean circulation, or a combination of both processes. A paleoproductivity reconstruction from biogenic Ba data suggests that glacial productivity was considerable lower than it was during interglacial stages. Model results suggest that the oxygen penetration depth, an indicator of sediment redox state, changed less than 1 cm as a result of the change in productivity. Changes in oxygen penetration depth estimated from Re and U removal depths are significantly larger, suggesting that changes in ventilation are a more important control on sediment redox state. Overall, trace metal results confirm the tight coupling between ocean circulation, marine productivity, and global change.