Geodetic measurements (GPS) in the eastern Mediterranean suggest higher rates of motion, of about 10 mm/yr, in the Aegean-Western Anatolian zone with respect to those in the central-eastern Anatolia. In this work we explore the plausibility of the hypothesis that the observed kinematics may be significantly influenced by post-seismic relaxation processes induced by the seismic activation of the North Anatolian Fault since 1939. The major implications of this hypothesis are tentatively quantified by a simplified model, constituted by an elastic lithosphere (100 km thick) coupled with a viscous asthenosphere (250 km thick with a viscosity of 1019 Pa s). The predicted perturbation of the displacement and stress fields is consistent with geodetic velocities and could also account for the major features of seismic activity in the period considered. ¿ 2001 American Geophysical Union