The middle Pliocene warm interval (ca. 3 Ma BP) has been extensively studied. However, our knowledge concerning the global distribution of middle Pliocene biomes remains far from complete. This paper presents the results from a first attempt at simulating the distribution of different mid-Pliocene biomes using an advanced numerical general circulation climate model (Hadley Centre Atmospheric Model Version 3) and the BIOME 4 vegetation model. The modeling indicates that during the middle Pliocene the geographical coverage of tundra type biomes may have been significantly reduced compared with the present day in the Northern Hemisphere. High-latitude forests expand in the place of tundra forms of vegetation. Total area covered by forest increases for the Pliocene case compared with the present day. Arid deserts become less prevalent in the Pliocene scenario and are replaced by tropical xerophytic shrublands and savanna-type vegetation. These results compare favorably with geological data in general and with the U.S. Geological Survey's PRISM2 middle Pliocene vegetation reconstruction, although data/model inconsistencies are apparent. Although some of these inconsistencies relate to the weaknesses of the climate and biome model employed, others identify deficiencies in the extant geological data set or the interpretation of this data. This modeled biome reconstruction will serve as a useful vehicle for aiding in future comparisons between geological data on middle Pliocene biomes and model predictions.