During the austral autumn of 1997, a sequence of record low ozone events with anomalous behavior occurred at subtropical latitudes to midlatitudes over southern South America, also known as the South Cone (Chile, Argentina, Uruguay, and Southern Brazil). The extreme low ozone events took place in May and early June 1997, i.e., at a time of the year when according to the climatological studies for Northern Hemisphere ozone miniholes, the most significant events would not be expected (if such studies could be simply extrapolated to the Southern Hemisphere). The first and most prominent ozone minihole, with a quasi-stationary evolution, reached values near 200 DU, i.e., a negative anomaly near 90 DU, close to 40¿S. Simultaneously, extreme weather conditions were observed over the South Cone: three significant blocking events took place separated by short intervals. Both the behavior of the ozone layer over the region and the evolution of the blocking events were analyzed. As expected, the evolution of the total ozone column is shown to be linked to these perturbed weather conditions. Despite the apparently similar nature of the blocking events and of the ozone decrease during each of these events, the present study shows that the response of the UT/LS region is different in each case. The respective roles of the vertical displacement of the tropopause and the horizontal advection/divergence of ozone is discussed for the two most important events, showing how these two mechanisms combine in different ways to yield very low total ozone values. The vertical displacement of the tropopause, coupled to the size of the tropopause pressure gradient, appears to be the most efficient mechanism to modify the total ozone column amounts.