We present results from an analysis of anisotropy in marine sediments using walkaway vertical seismic profiles from the Blake Ridge, offshore South Carolina. We encountered transverse isotropy (TI) with a vertical symmetry axis in a gas-hydrate-bearing unit of clay and claystone with Thomsen parameters ϵ = 0.05 ¿ 0.02 and δ = 0.04 ¿ 0.06. TI increased to ϵ = 0.16 ¿ 0.04 and δ = 0.19 ¿ 0.12 in the underlying gas zone. Rock physics modeling suggests that the observed TI is caused by a partial alignment of clay particles rather than high-velocity gas-hydrate veins. Similarly, the increase of TI in the gas zone is not caused by thin low-velocity gas layers but rather, we speculate, by the sharp contrast between seismic properties of an anisotropic sediment frame and elongated gas-bearing pore voids. Our results underscore the significance of anisotropy for integrating near-vertical and wide-angle seismic data.