Pyroclastic flows entering the sea are plausible mechanisms for tsunami generation at volcanic island arcs worldwide. We evaluate tsunami generation by pyroclastic flow using an example from Aniakchak volcano in Alaska where evidence for tsunami inundation coincident with a major, caldera-forming eruption of the volcano ca. 3.5 ka has been described. Using a numerical model, we simulate the tsunami and compare the results to field estimates of tsunami run up.