New evidence for uplift of the southern margin to the Corinth rift, one of the world's most rapidly extending continental regions, defines an area of uniform uplift separating a more rapidly uplifting western rift flank from a slowly backtilting eastern flank. This major tectonic boundary coincides with geophysical evidence for a junction between flat underlying subducted oceanic plate and steep subduction. We propose that trench rollback by the Anatolian plate over the subducting African plate has led to differential uplift and possible migration of active faulting at the southern rift margin in the last few million years.