The site response has been theoretically estimated along seven 2-D profiles distributed in the broader urban area of Thessaloniki. The hybrid method employed allows the simulation of various events located at different distances and azimuths around the city. We focus on the results obtained at all points where the profiles intersect. The diversity of the site response at each intersection is attributed mainly to the influence of the seismic source, suggesting that the ground response does not depend only on local soil characteristics but also on different earthquake scenarios generating the impingent wavefield.