Global measurements show that the mixing ratio of tropospheric methane (CH4) increased by 1.1% (19.5 ¿ 1.7 ppbv) over the five-year period 1996--2000, with striking fluctuations in its annual growth rate. Whereas the global CH4 growth rate reached 15.9 ¿ 0.7 ppbv yr-1 in 1998, the growth rate was -2.1 ¿ 0.8 ppbv yr-1 in 2000. This is the first time in our 23-year global monitoring program that we have measured a negative annual CH4 growth rate. The CH4 growth rate fluctuates in an unpredictable fashion, and we reemphasize that global CH4 concentrations cannot be extrapolated into the future based on past trends. As a result, we suggest that the slowing of the CH4 growth rate during much of the 1980s and 1990s cannot be used to imply that CH4 will no longer be of concern in greenhouse gas studies during this century.