The longest continuous series of ground-based measurements of mesospheric CO is presented. The continuous data cover the period September 2000 to September 2002. Sporadic measurements from 1988 and 1989 are also reported. The results show a large CO accumulation in the winter mesosphere, which is consistent with generally accepted ideas about the seasonally-varying mean meridional circulation. Comparison of the observations with simulations by the Whole Atmosphere Community Climate Model (WACCM) indicate that the model can reproduce the observed seasonal cycle as well as much of its variability, although calculated columns amounts are smaller than the largest values seen in the data.