The ionospheric response to the magnetic storm of 15 July 2000 is investigated using the global total electron content (TEC) maps provided by global positioning system and the measurements of ion density, composition, and drift velocity from the Defense Meteorological Satellite Program (DMSP) F13 and F15 spacecraft. The global TEC maps showed clear seasonal effects that can be characterized by a dominance of a negative ionospheric storm (decrease in plasma density) in the summer (northern) hemisphere and the pronounced positive ionospheric storm (increase in plasma density) in the winter (southern) hemisphere. The northern negative storm phase rapidly expanded to the equator at midnight and even penetrated to the opposite hemisphere during the storm main phase. In the southern hemisphere, the negative storm phase began in the morning sector but was confined to narrow latitude and local time sectors owing to strong poleward winds and ion drag on the dayside. The negative storm phases in the opposite hemispheres kept out of phase, lasted for a day, and corotated with Earth. These characteristics show good qualitative similarity with the predictions of global model simulations. The positive storm phase prevailed in the southern low-middle latitudes and was most pronounced during nighttime. In that region, the quiet time DMSP measurements at 1800 LT, 2100 LT, 0600 LT, and 0900 LT showed low ion density, low O+ proportion, and large downward ion drift velocity compared with those in the northern hemisphere. During storm time the O+ proportion and ion concentration increased to the levels seen in the northern hemisphere while the downward ion drift velocity was much decreased. The excellent temporal and spatial correspondence of the increase in ion concentration with the decrease in downward ion drift velocity indicates that the maintenance of the F layer at high altitudes by the storm-induced equatorward neutral winds was the main driver of the positive ionospheric storm. The quiet time hemispheric asymmetry was most significant at nighttime, and therefore the positive storm effect appeared most pronounced at nighttime in the winter hemisphere.