A field, microstructural, and geochronological study of contemporaneous plutonism and strike-slip faulting along the eastern Tonale fault zone provides new insights into the interrelationships between magmatic emplacement, contact metamorphism and shearing, and it places new time constraints for the Periadriatic Fault System. Although pluton emplacement and shearing were not caused by each other, they mutually interacted during contact metamorphism. The character of the composite Tonale fault zone varies considerably with its proximity to the northern margin of the Adamello pluton, from a paired greenschist facies mylonite belt (Northern mylonite zone) and cataclastic fault zone in the west, to a fault zone consisting of Northern mylonite zone, Cataclastic fault zone and a second mylonite belt (Southern mylonite zone) formed by contemporaneous shearing and contact metamorphism in the east. Ongoing strike-slip motion led to telescoping and advective cooling of the deforming contact aureole. New U/Pb zircon ages for the northernmost Adamello intrusions (the Avio at 34.6-1.0 Ma and the Presanella at 32.0-2.3 Ma) date the onset of contact metamorphism. Rb-Sr and K-Ar cooling ages and new zircon fission track ages provide evidence that postintrusive cooling to below 300¿C was achieved rapidly, i.e., approximately 30 Myr ago being consistent with a shallow crustal emplacement at ambient temperatures of approximately 250¿C. Cataclastic dextral strike-slip faulting continued until about 20 Ma, when the Tonale fault zone became offset by a number of minor sinistral shears, and by the Giudicarie fault. Hence dextral strike-slip motion along the Periadriatic Fault System east of the Bergell pluton lasted from approximately 35--20 Myr ago.