Bioremediation can be a cost-effective approach to clean up groundwater contaminants, especially in cases where numerical models have been used to evaluate microbial processes and design remediation strategies. This paper describes the three-dimensional reactive transport modeling of carbon tetrachloride (CT) bioremediation at the Schoolcraft site in western Michigan. A biocurtain was created to remediate this site using a recirculation well gallery installed normal to groundwater flow, which was inoculated with nonnative microbes and fed with weekly additions of electron donor (acetate) and nutrients. The model simulates the transport and reactions of aqueous and sorbed phase CT, acetate, electron acceptor (nitrate), mobile and immobile microbes, and tracer (bromide). Simulated microbial processes include growth, decay, attachment, detachment, and endogenous respiration. This model was used to predict solute concentrations across the site using laboratory-based reaction parameters and to evaluate changes in rates from the laboratory to the field. A reasonable agreement was found between predicted and observed acetate and nitrate concentrations; however, a lower CT degradation rate was needed to describe the CT concentrations observed after the inoculation event.