The dependence on the mean climate state of the response of the Atlantic meridional overturning circulation (AMOC) is investigated in 17 increasing greenhouse gas experiments with different initial conditions. The AMOC declines in all experiments by 15% to 31%, with typically the largest declines in those experiments with the strongest initial AMOC. In all cases, changes in surface heat fluxes, rather than changes in surface freshwater fluxes, are the dominant cause for the transient AMOC decrease. Surface freshwater fluxes actually switch from reducing the transient AMOC decrease, for low values of atmospheric CO2, to reinforcing the transient AMOC decrease, for higher values of atmospheric CO2. In addition, we find that due to changes in the strengths of feedbacks associated with water vapour and snow/sea ice, the climate sensitivity and transient climate response of the UVic model strongly depends on the mean climate state.