The Alpine Oligocene plutons are spatially and temporally associated with the activity of the Periadriatic Fault System (PFS), an orogen-parallel, crustal-scale transpressive mylonitic belt. Excellent three-dimensional exposure, combined with a wealth of structural, seismic, petrological, geochronological, geochemical, and paleomagnetic data collected over the last decades help to constrain the relationships between deformation, ascent, and emplacement of the plutons. Magmas were channeled from the base of the thickened continental crust into the narrow mylonitic belt of the Periadriatic Fault System, which was used as ascent pathway to cover vertical lengths of 20 to 40 km. Therefore the linear alignment of the plutons at the surface is not the expression of a linear source region at depth. Ascent of the melts is controlled by the mylonitic foliation of the PFS, which forms the only steep anisotropy, continuously traversing the entire Alpine crust. In contrast, the flow direction is not influenced by the specific kinematics of the faults. Final emplacement of the plutons occurred by extrusion from the Periadriatic Fault System into the adjacent country rocks. The transition from ascent to final emplacement is favored by partitioning of transpressive deformation.