The Jurassic Karoo large igneous province consists of vast quantities of basaltic lava flows, giant dike swarms, and poorly dated silicic magmatism. The Karoo magmatism occurred over more than 3 W 106 km2 and was associated with the opening of the Indian Ocean. We present new 40Ar/39Ar geochronological data concerning the easternmost part (i.e., the Mwenezi and Lebombo areas) of the Karoo province, close to the future rifted margin. These data allow documenting the final history of the province and the time elapsed between the end of the Karoo magmatism and the inception of oceanization. This important type of information is poorly constrained for most of the large igneous provinces. Eighteen plagioclase separates yielded 14 plateau and "mini-plateau" ages obtained on 3 basaltic dikes (178.1 1 1.1 to 177.2 1 2.4 Ma; 2σ), 3 gabbroic (178.2 1 1.7 to 176.8 1 0.7 Ma) and 2 silicic (175.8 1 0.7 to 174.4 1 0.7 Ma) plutons, and 1 rhyolitic lava flow (177.8 1 0.7 Ma). We also obtained three concordant plateau and mini-plateau ages ranging from 173.9 1 0.7 Ma to 172.1 1 2.3 Ma on the atypical E-MORB-like N--S striking Rooi Rand dikes. One dike from the Save-Limpopo N700-oriented giant dike swarm provides a mini-plateau age of 177.7 1 0.8 Ma in agreement with the dates previously determined on this branch and possibly assessing the same age and short duration (≤1--2 Myr) as for the 179 Ma giant Okavango dike swarm. New and previous selected age data obtained on the Karoo province show that the magmatism was active over ~10 Myr from 184 to 174 Ma. The main basaltic phase occurred mostly over the first ~5 Myr and was progressively followed by a more differentiated and less voluminous magmatism over the last 4 Myr. The easternmost Lebombo-Mwenezi long-lasting magmatism is interpreted as being triggered by the progressive lithospheric extension preceding the continental disruption. The transition from rifting to oceanization is probably illustrated by the E-MORB-like Rooi Rand dikes which are likely to be emplaced during or shortly after the final stage of the Karoo magmatism. A geodynamic evolution of the province is proposed. These data indicate that the Karoo magmatism represents an atypical province (admitting that other large igneous provinces are sufficiently known) with a long-lasting and relatively low-emission rate magmatic activity. It appears from a reevaluation of major Phanerozoic Continental Flood Basalts (CFBs) that for most of them, including the Karoo, the onset of oceanization shortly follows (or is coeval to) the latest CFB-related activity more closely than previously thought.