We used teleseismic travel time residuals to determine lateral velocity variations of the crust and upper mantle in the Pamir-Hindu Kush region in Tadjikistan and Afghanistan. Data from 29 analog seismic stations in Tadjikistan and northern Afghanistan were used to determine travel time residuals for 210 teleseismic events ranging in distance from 28¿ to 87¿ and covering a broad range of azimuths. We inverted for velocity perturbations over a rectangular grid with a block size of 99¿99 km. The model extended to a depth of 350 km with a 50-km-thick first layer and two 150-km-thick deeper layers. The results show a strong and well-resolved zone of high velocities in the upper mantle at depths greater than 200 km, coincident with the location of the Hindu Kush seismic zone. No clear velocity perturbations are associated with the Pamir seismic zone. Above 200 km little correlation is observed with the seismic zone, but indications of thicker crust under the Pamir and thinner crust under the Tadjik Depression are seen. The high velocities are most likely caused by the presence of oceanic lithosphere at depth. ¿ American Geophysical Union 1995