We have analyzed the spectral content of free air gravity anomalies in the Caribbean-South American plate boundary zone in order to determine better the near-surface (0--120 km) distribution of crustal and upper mantle elements which give rise to the unusual gravity field of this region. The plate boundary zone in northeastern Venezuela and Trinidad is the site of the world's sea level continental minimum of Bouguer gravity anomalies, yet the region is also one of mild topography (mean value, 43 m, maximum, 1200 m). We find the mean depths to interfaces of significant density contrast at a variety of depths for portions of the plate boundary zone. We interpret interfaces at 30--35 km and 32 km beneath the Guyana Shield and the Aves Ridge, respectively, to be the Moho. Other shallow interfaces (5--14 km) are most likely sediment cover basement contacts in the Maturin foreland basin and southern Grenada Basin. Deeper interfaces (54--63 km) we associate with loaded and downwarped continental and oceanic South American lithosphere. The deepest boundaries, at depths of 89--120 km, may be related to detached or detaching oceanic lithosphere overridden by continental South America. We use our results to test the tectonic wedging model of the plate boundary zone recently published by Russo and Speed (1992). We find that the tectonic wedging model adequately describes many of the structural boundaries inferable from our analysis of gravity anomalies but that the model must be modified to include a thinner Guyana Shield crust.